MagBio Genomics, a leading provider of magnetic bead-based sample preparation technologies, announces the launch of its newly optimized HighPrep™ magnetic bead DNA purification kits. These kits are designed to meet the evolving needs of genomics laboratories worldwide by offering unparalleled flexibility, reliability, and performance for DNA cleanup workflows. Whether for next-generation sequencing (NGS), PCR, or other molecular biology applications, HighPrep™ positions itself as the industry’s most versatile and cost-effective purification solution.
As the demand for precise DNA purification grows across research and clinical markets, HighPrep™ steps in with a platform-agnostic system that exceeds expectations. Its unique SPRI (Solid Phase Reversible Immobilization) bead chemistry ensures consistent DNA recovery, minimal contamination, and compatibility with both manual and automated systems. With HighPrep™, MagBio delivers a reagent kit that outperforms spin columns and matches—if not exceeds—the efficiency of other SPRI bead systems like AMPure XP.
Key Features and Benefits
1. Superior Magnetic Bead DNA Purification
HighPrep™ uses a high-performance magnetic bead matrix to isolate and purify DNA efficiently across a wide fragment range (100 bp to >50 kb). Whether you're working with small amplicons or high molecular weight DNA, the bead formulation ensures optimal recovery without compromising purity.
2. Best-in-Class SPRI Bead DNA Purification Kit
Compared to other kits in the market, including proprietary systems, HighPrep™ consistently delivers:
● Higher yield per input
● Minimal salt and ethanol carryover
● Uniform bead suspension for reproducibility
● Compatibility with multiple protocols (NGS, qPCR, methylation assays)
3. Automation Ready
HighPrep™ kits are validated for use with major liquid handling systems such as:
● Thermo Fisher KingFisher Flex
● Hamilton STAR
● Tecan Fluent and Evo platforms
● Beckman Biomek series
This makes HighPrep™ ideal for core facilities, high-throughput labs, and diagnostic workflows where time and precision are critical.
4. Versatile for Single and Double-Sided Size Selection
Unlike fixed-protocol systems, HighPrep™ allows full control over SPRI ratios to perform both single and double-sided size selection. This is especially useful in library construction for NGS platforms like Illumina and PacBio.
5. Cost-Efficiency Without Compromise
HighPrep™ kits cost up to 40% less per sample compared to leading SPRI bead products. With no sacrifice in yield or quality, labs can stretch budgets further and increase project scalability.
Performance Across Applications
HighPrep™ has been field-tested and adopted across various genomic workflows, demonstrating its value in:
NGS Library Preparation:
Used for post-PCR and adapter ligation cleanup, HighPrep™ ensures optimal insert sizes and minimizes adapter dimer contamination.
PCR and Amplicon Purification:
Removes primers, dNTPs, and polymerases efficiently while preserving product concentration.
Methylation-Sensitive Assays:
Supports bisulfite-treated DNA cleanup with minimal degradation or loss.
Long-Read Sequencing Prep:
High molecular weight DNA is recovered with minimal shearing—ideal for PacBio and Oxford Nanopore workflows.
Target Enrichment Panels:
Accurate size selection enhances on-target reads and reduces off-target noise.
Real-World Validation
A recent comparative study at a mid-size academic genomics core found that HighPrep™:
● Improved DNA recovery by 8–12% compared to AMPure XP
● Reduced bead loss and protocol time by 25%
● Maintained fragment integrity even after extended incubation
"We were skeptical initially, but after running parallel preps, HighPrep™ not only matched our benchmarks—it exceeded them," reported the lab manager. "The flexibility and cost savings were game changers."
Differentiating from Competitors
HighPrep™ was designed to address pain points experienced with conventional kits:
● No more clumping: Uniform bead dispersion means consistent results
● Scalable formats: Available in 5 mL, 50 mL, and bulk packaging
● Flexible storage: Stable at 4°C without degradation
● Transparent pricing: Clear volume-based pricing without hidden markups
Most importantly, HighPrep™ removes the need to choose between price and performance. Labs can finally get both.
Protocol and Usage Highlights
HighPrep™ supports standard workflows and can be adapted to specific protocols using simple ratio adjustments:
Cleanup After PCR
● 1.8x bead ratio for total recovery
● Incubation: 5 min at room temp
● Wash: 2x with 80% ethanol
● Elution: 10 μL nuclease-free water or buffer
Double-Sided Size Selection (NGS)
● First cut: 0.5x ratio to exclude large fragments
● Second cut: Add 0.3x to reach total of 0.8x for exclusion of small fragments
● Final elution: High-quality fragments in 300–800 bp range
Frequently Asked Questions
Q: What makes HighPrep™ different from other SPRI bead kits?
A: Higher recovery, no clumping, platform-agnostic design, validated automation protocols, and 40% cost savings.
Q: Can I use HighPrep™ with FFPE samples?
A: Yes. HighPrep™ works with low-input and degraded samples including FFPE, with optimized recovery protocols.
Q: Are there minimum sample input requirements?
A: HighPrep™ performs well with input from as low as 5 ng DNA and up to several micrograms.
Q: Is it compatible with third-party enzymes and adapters?
A: Yes. HighPrep™ is compatible with all standard library prep kits and enzymes.
Technical Support and Resources
MagBio provides an extensive library of user protocols, video tutorials, and FAQs. Technical support is also available via email or virtual consultation. Customized workflow validation support is offered for new automation clients.
How to Order
HighPrep™ kits are available in several configurations:
● 5 mL (50–100 preps)
● 50 mL (500–1,000 preps)
● Bulk and OEM versions for industrial and diagnostic partners
Ordering is available directly from MagBio Genomics or via authorized distributors. Online ordering with credit card support and global shipping is available.
About MagBio Genomics
Founded in 2011, MagBio Genomics is a biotechnology company specializing in magnetic bead-based sample prep technologies. With a focus on NGS, molecular diagnostics, and high-throughput automation, MagBio is trusted by thousands of labs worldwide.
The company’s product line includes:
● HighPrep™ PCR Clean-Up Kits
● HighPrep™ FFPE DNA/RNA Extraction Kits
● HighPrep™ Total Nucleic Acid Purification Solutions
● SFD-10HT for circulating DNA
Discover why HighPrep™ is the magnetic bead DNA purification kit of choice for genomic scientists worldwide. With proven performance, unmatched flexibility, and unbeatable cost savings, HighPrep™ simplifies every step of your DNA cleanup process.
