What Is Cannabidivarin (CBDV)? | Macon Acres
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When discussing the components in cannabis it is easy to get caught on THC as well as CBD. They are at the end of the day the most important components of the plant. But, there is a myriad of compounds found in cannabis which, despite their tiny existence, can influence how the plant impacts us. Cannabidivarin also known as CBDV is one such chemical.
THC along with CBD has risen to the forefront of the cannabis debate. The plant’s history is rich in numerous compounds, many of which work in different ways, delivering many benefits. This article will look at an in-depth look at cannabidivarin or CBDV Products which is a widely underrated cannabinoid that has a lot of potential.
What Is CBDV?
CBDV is among the more than 100 cannabinoids created from the plant cannabis. Similar to the other “secondary” cannabinoids, CBDV typically occurs in lower levels than THC or CBD generally and tends to be found more in cannabis with low THC levels like hemp.
CBDV For Sale is a non-intoxicating cannabis cannabinoid that doesn’t trigger the euphoric, euphoric stone that we usually associate with cannabis strains that are high in THC. CBD is a homolog of CBDV as both have very similar chemical structures and mechanisms of action which we’ll explore more in depth below.
How Does CBDV Work?
Like many cannabinoids, there’s much we don’t know about CBDV Products or its mechanism of action. But preliminary tests of this cannabinoid provide us with an idea at the very least of how it could affect our bodies.
Like its cannabinoid counterpart (CBD), CBDV For Sale doesn’t exhibit a strong affinity to the cannabinoid receptors CB1 as well as CB2. This is among the reasons CBDV does not cause the typical intoxication effects found in cannabis.
Studies suggest that, just like CBD cannabidivarin, cannabidivarin could also be able to affect other chemical pathways, and may interplay with our endocannabinoid process in an indirect manner. For instance, clinical trials exploring the efficacy of CBDV for treating epilepsy and convulsions indicate that CBDV is able to activate and reduce the sensitivity of TRPV1 receptors (also called capsaicin receptors) which are essential to our ability to detect discomfort and sense temperatures. Studies have also shown that CBDV might act on TRPV2 or TRPA1 receptors.
Each of these receptors falls within the category of transient potential channels. They are embedded in the cell membrane and when activated, they open to let huge amounts of ions (such as sodium for instance) enter the cell.
Research suggests that CBDV Products could hinder the activity of diacylglycerol Lipase, one of the most important enzymes that are involved in the production of 2AG. It is an endocannabinoid that is naturally created by the body. What exactly CBDV For Sale does this, however, isn’t completely clear.
What Does CBDV Do?
CBDV has been the subject of numerous studies and trials. However, we know little about this cannabinoid, its mechanisms of action, and its potential for therapeutic use than we know about CBD.
In the next section, we’ll go through the latest CBDV Products research and then look at what it provides us with regard to its purpose and future potential. Be aware that these findings are preliminary.
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CBDV and Epilepsy
In 2013 in 2013, The British Journal of Pharmacology published research that looked at the effects of CBDV on mice and rats. The mice were fed cannabis extracts from plants (in different amounts) that were high in CBDV For Sale They also contained CBD and pure versions that contained both cannabinoids. Researchers also employed an isobologram to study how both cannabinoids interacted and to gain a better understanding of the effects they have upon the human body.
The mice and rats were then induced to experience seizures by using pentylenetetrazole (a stimulant for the respiratory and circulatory systems) as well as pilocarpine as well as an audiogenic model of the seizure (in which the animals are kept in a separate chamber, and then exposed to an audio stimulus which triggers a seizure). Researchers employed this model to study the anticonvulsant properties of CBDV-rich extracts. the results of the analysis of isobolograms revealed that CBDV exhibited its effects without affecting CB1 receptors.
In 2014 in 2014, the ACS Chemical Neuroscience journal also released a study that examined the anticonvulsant effects of CBDV. The study found that CBDV’s effects were mediated through TRP channels (as previously described).
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CBDV and Autism
With CBDV’s potential to modulate the inhibitory and excitatory mechanisms in the brain, Some studies have examined the therapeutic possibilities of CBDV For Sale in dealing with the main characteristics of autism spectrum disorder.
In the year 2019, the journal Translational Psychiatry took this premise and tested it to determine whether CBDV Products can affect glutamate levels and GAMA metabolic compounds (markers for the brain’s inhibitory and excitatory systems) as well as in healthy people and those with autism spectrum disorders. The study was conducted in an open-blind, randomized-order cross-over approach, and utilized magnetic resonance spectroscopy for measuring GABA+ and glutamate GABA+ levels in 34 males (17 of whom had autism, and the other 17 who did not) in the aftermath of treatment with a placebo and 600 mg of CBDV.
The study’s authors affirm that CBDV had an impact on the levels of glutamate within the brains of both types of participants. The results did not appear to be uniform for every person and the researchers found that more studies were required to determine CBDV’s effectiveness as a treatment for autism-related symptoms. spectrum disorders.
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CBDV and Nausea
A lot of people have reported that they use cannabis for nausea, stomach upset, or vomiting. Therefore, there’s been an increasing interest in examining how cannabinoids can affect the body’s natural nausea response.
In 2013, the British Journal of Pharmacology published an examination of CBDV’s potential as an antiemetic in the animal model of nausea. The researchers of the study initially used two inverse agonists for the CB1 receptor to cause nausea in laboratory rats. They then conducted two tests to determine whether CBDV as well as THCV either caused nausea or decreased the amount of nausea. In the end, the study states that neither THCV nor CBDV performed in the same way as CB1 reverse agonists and, in turn, seemed to decrease markers that are associated with stomach discomfort in the subjects tested.
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CBDV and Rett Syndrome
Rett syndrome is a genetic condition that affects women in particular and affects the brain development of women. It is characterized by severe disabilities that limit a person’s capacity to communicate, control their body, develop and grow correctly, and much more.
The endocannabinoid system is responsible for several of the biological functions that are affected by Rett syndrome Researchers have decided to investigate the efficacy of CBDV in treating this disorder. In particular, a report published in Neuropharmacology looked at how CBDV Products affect CBDV in a model animal of Rett syndrome. Following 14 days of therapy with CBDV the researchers noticed improvements in the health condition of the mice and also improvements in the severity of behavioral impairment as well as a slowing of the atrophy of the brain.
Note: Although the research above is intriguing and fascinating it’s not enough to draw any definitive conclusions regarding CBDV and its possible health benefits. We know less about CBDV than regarding other cannabinoids. much more research is required to comprehend its entire range of effects.