Sanare Lab Fenbendazole

Fenbendazole is a widely used antihelminth with mechanisms of action that overlap with those of hypoxia-selective nitroheterocyclic cytotoxins/radiosensitizers and the taxanes. This agent was evaluated in combination with radiation and chemotherapeutics in the EMT6 mouse mammary tumor cell line in vitro and as solid tumors in mice. Febenazole alone produced no cytotoxicity in vitro but was highly effective in combination with both radiation and docetaxel in inhibiting the growth of EMT6 cells and increasing the antineoplastic effects of these agents. In vivo, fenbendazole was less effective in inhibiting tumor growth but was equally effective with radiation in reducing the number of spontaneous lung metastases at necropsy.

Intensive treatments of fenbendazole in culture did not alter the dose-response curves for radiation or docetaxel. In the xenograft model, fenbendazole and the supplemental vitamins did not alter the rate of tumor development or increase the antineoplastic activity of radiation or docetaxel. However, the initial inhibition of tumor growth was diminished by a factor of approximately 50% at subsequent measurements in both groups of mice. This may have been due to the fact that the diet containing fenbendazole and the additional vitamins was within its expiration date (6 mo) at the time of this study, and so vitamin concentrations were lower than they had been in the diet used for the first observations.

Sanare lab fenbendazole is an over the counter medication that works against parasitic infections in humans and animals. It also boosts p53 levels, which can help fight cancer in patients who have a mutated p53 gene. Moreover, this dewormer can also destroy microtubules in cancer cells and inhibit their growth.