Prader-Willi Syndrome Market Size to Reach USD XX Billion by 2034, estimates DelveInsight
DelveInsight’s recent analysis estimates that the global Prader-Willi Syndrome (PWS) market was valued at USD 1.53 billion in 2021 and is expected to grow at a high CAGR during the forecast period from 2022-2030. The growth can be primarily attributed to an increase in awareness about the syndrome, improving diagnostic rates, and new therapies in the pipeline.
Prader-Willi syndrome (PWS) is a rare genetic disorder characterized by an insatiable appetite and extreme obesity beginning in early childhood. It occurs in approximately 1 in 15,000 births and is more common in boys than girls. The major features of PWS include muscular hypotonia, mental disability, short stature, behavioral issues such as temper tantrums and stubbornness, distinctive facial features, and excessive eating, leading to obesity.
The current Prader-Willi Syndrome Market is majorly being driven by somatropin biologics capturing almost 90% market share. The growth hormones help to increase lean muscle mass and are one of the only drugs currently approved to treat growth failure in children with PWS. Key growth hormone brands include Pfizer’s Genotropin, Novo Nordisk’s Norditropin, Eli Lilly’s Humatrope, and Merck’s Nutropin AQ.
However, the market is expected to evolve significantly with emerging gene therapies which can potentially modify disease progression. For instance, Soleno’s DCCR tablet aims to restore functional leptin receptor sensitivity, thereby reducing hyperphagia and related behaviors. The US FDA granted DCCR Fast Track designation in 2018 and Orphan Drug status in 2010.
Likewise, Levo Therapeutics’ LV-101 gene therapy utilizes a zinc finger protein transcriptional repressor to downregulate expression of genes lacking paternal contribution on chromosome 15. LV-101 has received orphan drug designation in both the US and Europe. With promising clinical data, emerging gene-targeted therapies are expected to gain rapid traction over the coming years.
Geographically, North America dominated the PWS market in 2021, with the US alone constituting around 90% market share due to high diagnosis rates and favorable reimbursement policies. Europe accounts for the second largest market share, trailed by the Asia Pacific and rest of the world. With improving healthcare infrastructure and increasing healthcare spending across developing regions, the APAC PWS market will grow at the fastest rate during the forecast period.
Overall, Prader-Willi Syndrome remains an underdiagnosed condition with several unmet needs. However, with disease awareness programs by patient advocacy groups and government healthcare bodies as well as R&D in genetic medicines by pharma companies, the PWS therapeutics domain looks promising over the coming decade. The influx of targeted therapies is set to transform the treatment landscape while lowering long-term disease burden.
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